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What is GABA? (gamma-aminobutyric acid)

GABA, or gamma-aminobutyric acid, is the most abundant inhibitory neurotransmitter in the brain. While GABA is an amino acid, it is classified as a neurotransmitter and helps induce relaxation and sleep. It balances the brain by inhibiting over-excitation. GABA contributes to motor control, vision, and many other cortical functions. Anxiety is also regulated by GABA. Some drugs that increase the level of GABA in the brain are used to treat epilepsy and to calm the trembling of people suffering from Huntington’s disease.

Gamma-aminobutyric acid also stimulates the anterior pituitary, leading to higher levels of Human Growth Hormone (HGH). Human Growth Hormone contributes significantly to muscle growth and also prevents the creation of fat cells. Moreover, HGH depletion is prevalent in adults over the age of 40 and may be responsible for sleep disturbances or interrupted sleeping patterns.

Natural alternative medicines have been shown to act directly on the GABAnergic system, allowing for greater availability of this neurotransmitter. This effect is believed to be partially responsible for improvement in those individuals taking natural alternative GABA antagonists like Valerian root.


References

1. ^ Watanabe M, Maemura K, Kanbara K, Tamayama T, Hayasaki H (2002). "GABA and GABA receptors in the central nervous system and other organs". Int. Rev. Cytol. 213: 1–47. doi:10.1016/S0074-7696(02)13011-7. PMID 11837891.

2. ^ Szabadics J, Varga C, Molnár G, Oláh S, Barzó P, Tamás G (January 2006). "Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits". Science 311 (5758): 233–5. doi:10.1126/science.1121325. PMID 16410524.

3. ^ a b Li K, Xu E (June 2008). "The role and the mechanism of gamma-aminobutyric acid during central nervous system development". Neurosci Bull 24 (3): 195–200. doi:10.1007/s12264-008-0109-3. PMID 18500393.

4. ^ Popp A, Urbach A, Witte OW, Frahm C (2009). "Adult and embryonic GAD transcripts are spatiotemporally regulated during postnatal development in the rat brain". PLoS ONE 4 (2): e4371. doi:10.1371/journal.pone.0004371. PMID 19190758. PMC 2629816. http://dx.plos.org/10.1371/journal.pone.0004371.

5. ^ Purves D, Fitzpatrick D, Hall WC, Augustine GJ, Lamantia A-S (2007). Neuroscience (4th ed.). Sunderland, Mass: Sinauer. pp. 135, box 6D. ISBN 0-87893-697-1.

6. ^ Jelitai M, Madarasz E (2005). "The role of GABA in the early neuronal development" ([dead link]). Int. Rev. Neurobiol. 71: 27–62. doi:10.1016/S0074-7742(05)71002-3. PMID 16512345. http://www.iem.cas.cz/Data/files/pdf/neuroscience/2004/jelitai-2004.pdf.

7. ^ LoTurco JJ, Owens DF, Heath MJ, Davis MB, Kriegstein AR (December 1995). "GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis". Neuron 15 (6): 1287–98. doi:10.1016/0896-6273(95)90008-X. PMID 8845153.

8. ^ Haydar TF, Wang F, Schwartz ML, Rakic P (August 2000). "Differential modulation of proliferation in the neocortical ventricular and subventricular zones". J. Neurosci. 20 (15): 5764–74. PMID 10908617. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=10908617.

9. ^ Behar TN, Schaffner AE, Scott CA, O'Connell C, Barker JL (August 1998). "Differential response of cortical plate and ventricular zone cells to GABA as a migration stimulus". J. Neurosci. 18 (16): 6378–87. PMID 9698329. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=9698329.

10. ^ Barbin G, Pollard H, Gaïarsa JL, Ben-Ari Y (April 1993). "Involvement of GABAA receptors in the outgrowth of cultured hippocampal neurons". Neurosci. Lett. 152 (1-2): 150–4. doi:10.1016/0304-3940(93)90505-F. PMID 8390627.

11. ^ Ganguly K, Schinder AF, Wong ST, Poo M (May 2001). "GABA itself promotes the developmental switch of neuronal GABAergic responses from excitation to inhibition". Cell 105 (4): 521–32. doi:10.1016/S0092-8674(01)00341-5. PMID 11371348.

12. ^ Maric D, Liu QY, Maric I, Chaudry S, Chang YH, Smith SV, Sieghart W, Fritschy JM, Barker JL (April 2001). "GABA expression dominates neuronal lineage progression in the embryonic rat neocortex and facilitates neurite outgrowth via GABA(A) autoreceptor/Cl- channels". J. Neurosci. 21 (7): 2343–60. PMID 11264309. http://www.jneurosci.org/cgi/pmidlookup?view=long&pmid=11264309.

13. ^ Ben-Ari Y (September 2002). "Excitatory actions of gaba during development: the nature of the nurture". Nat. Rev. Neurosci. 3 (9): 728–39. doi:10.1038/nrn920. PMID 12209121.

14. ^ Obrietan K, Gao XB, Van Den Pol AN (August 2002). "Excitatory actions of GABA increase BDNF expression via a MAPK-CREB-dependent mechanism--a positive feedback circuit in developing neurons". J. Neurophysiol. 88 (2): 1005–15. PMID 12163549. http://jn.physiology.org/cgi/pmidlookup?view=long&pmid=12163549.

15. ^ Wang DD, Kriegstein AR, Ben-Ari Y (2008). "GABA Regulates Stem Cell Proliferation before Nervous System Formation". Epilepsy currents / American Epilepsy Society 8 (5): 137–9. doi:10.1111/j.1535-7511.2008.00270.x. PMID 18852839.

16. ^ Erdö SL, Wolff JR (1990). "gamma-Aminobutyric acid outside the mammalian brain". J. Neurochem. 54 (2): 363–72. doi:10.1111/j.1471-4159.1990.tb01882.x. PMID 2405103.

17. ^ Xiang, Y.; Wang, S.; Liu, M.; Hirota, J.; Li, J.; Ju, W.; Fan, Y.; Kelly, M. et al. (2007). "A GABAergic system in airway epithelium is essential for mucus overproduction in asthma". Nature medicine 13 (7): 862–867. doi:10.1038/nm1604. PMID 17589520. edit

18. ^ Payne, Anita H.; Matthew H. Hardy (2007). The Leydig cell in health and disease. Humana Press. ISBN 1588297543, ISBN 9781588297549.

19. ^ Kwakowsky, A.; Schwirtlich, M.; Zhang, Q.; Eisenstat, D.; Erdélyi, F.; Baranyi, M.; Katarova, Z.; Szabó, G. (2007). "GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5". Developmental dynamics : an official publication of the American Association of Anatomists 236 (12): 3532–3544. doi:10.1002/dvdy.21361. PMID 17969168. edit

20. ^ Devashis Majumdar and Sephali Guha.(1988). "Conformation, electrostatic potential and pharmacophoric pattern of GABA (gamma-aminobutyric acid) and several GABA inhibitors." Journal of Molecular Structure: THEOCHEM 180: 125-140. doi:10.1016/0166-1280(88)80084-8

21. ^ Anne-Marie Sapse. Molecular Orbital Calculations for Amino Acids and Peptides. Birkhäuser, 2000. ISBN 0817638938.

22. ^ Roth, Robert J.; Cooper, Jack R.; Bloom, Floyd E. (2003). The Biochemical Basis of Neuropharmacology. Oxford [Oxfordshire]: Oxford University Press. pp. 416 pages. ISBN 0-19-514008-7.

23. ^ Petroff OA (December 2002). "GABA and glutamate in the human brain". Neuroscientist 8 (6): 562–73. doi:10.1177/1073858402238515. PMID 12467378. http://nro.sagepub.com/cgi/pmidlookup?view=long&pmid=12467378.

24. ^ Schousboe A, Waagepetersen HS (2007). "GABA: homeostatic and pharmacological aspects". Prog. Brain Res. 160: 9–19. doi:10.1016/S0079-6123(06)60002-2. PMID 17499106.

25. ^ Foster AC, Kemp JA (February 2006). "Glutamate- and GABA-based CNS therapeutics". Curr Opin Pharmacol 6 (1): 7–17. doi:10.1016/j.coph.2005.11.005. PMID 16377242.

26. ^ Kuriyama K, Sze PY (January 1971). "Blood-brain barrier to H3-gamma-aminobutyric acid in normal and amino oxyacetic acid-treated animals". Neuropharmacology 10 (1): 103–8. PMID 5569303.

27. ^ a b Müller EE, Locatelli V, Cocchi D (April 1999). "Neuroendocrine control of growth hormone secretion". Physiol. Rev. 79 (2): 511–607. PMID 10221989. Free full-text.

28. ^ Powers ME, Yarrow JF, McCoy SC, Borst SE (January 2008). "Growth hormone isoform responses to GABA ingestion at rest and after exercise". Medicine and science in sports and exercise 40 (1): 104-10. ISSN 1530-031. PMID 18091016. http://www.ncbi.nlm.nih.gov/pubmed/18091016.

29. ^ Dzitoyeva S, Dimitrijevic N, Manev H (2003). "Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence". Proc. Natl. Acad. Sci. U.S.A. 100 (9): 5485–90. doi:10.1073/pnas.0830111100. PMID 12692303.

30. ^ Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL (1997). "Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors". Nature 389 (6649): 385–9. doi:10.1038/38738. PMID 9311780.

31. ^ Boehm SL, Ponomarev I, Blednov YA, Harris RA (2006). "From gene to behavior and back again: new perspectives on GABAAreceptor subunit selectivity of alcohol actions". Adv. Pharmacol. 54: 171–203. doi:10.1016/j.bcp.2004.07.023. PMID 17175815.

32. ^ Dimitrijevic N, Dzitoyeva S, Satta R, Imbesi M, Yildiz S, Manev H (2005). "Drosophila GABAB receptors are involved in behavioral effects of gamma-hydroxybutyric acid (GHB)". Eur. J. Pharmacol. 519 (3): 246–52. doi:10.1016/j.ejphar.2005.07.016. PMID 16129424.

33. ^ "Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity". http://www.ncbi.nlm.nih.gov/pubmed/19165747. Retrieved 2010-03-08.