Phosphatidylserine Presents Unique Neuroceutical Benefits
Being orthomolecular, deeply integrated into human biochemistry, endows PHOSPHATIDYLSERINE with exceptional efficacy, tolerability and safety. This helps to explain the superiority of Phosphatidylserine over herbal preparations like Ginkgo biloba extract, vinpocetine and huperzine, none of which has substantial orthomolecular character.
PHOSPHATIDYLSERINE is present in all our cells, tissues, and organs, and it has profound roles in energetics, repair and renewal. But it is in the brain that PHOSPHATIDYLSERINE most shines. PHOSPHATIDYLSERINE is a key cell membrane phospholipid, important for the brain cells to make energy via their mitochondrial membrane systems. PHOSPHATIDYLSERINE also is essential to the packaging of the nerve transmitters into membrane vesicles, to transmitter release via membrane fusion, and to transmitter actions on receptors embedded in the nerve cell membranes. Altogether, these activities translate into whole-brain effects that explain the documented clinical benefits of PHOSPHATIDYLSERINE.
Recently it was discovered that the brain can produce new nerve cells, under the influence of growth factors. In animal experiments PHOSPHATIDYLSERINE protected the receptors for nerve growth factor (NGF) against age-related loss, while conserving the existing circuits. This is consistent with its clinical brain revitalization effects.
A good dosing strategy with PHOSPHATIDYLSERINE is to preload the body's cell membrane systems with the clinically verified dose of 300 mg per day for a minimum one month, or for longer depending on need. Most people experience benefit within three weeks to three months. Then depending on need, a maintenance dose can be implemented, minimally 100 mg up to 300 mg per day.
The premier status of PHOSPHATIDYLSERINE as a neuroceutical grows out of decades of controlled clinical application. Its unique biochemistry, metabolism and range of proven benefits take it beyond the drugs and other nutrients that target the brain. For people of all ages, taking PHOSPHATIDYLSERINE offers hope for a level of brain sharpness that defies the passing of the years.
What can Phosphatidylserine (PS) do for Me?
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Phosphatidylserine increases metabolism throughout your entire brain.
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(Above:) PET imaging of the brain of a 59-year-old woman. The color scale indicates regional glucose metabolism at three brain levels, red is most intense and blue is least. UPPER: before Phosphatidylserine LOWER: after taking Phosphatidylserine® daily for three weeks.
Over 3,000 published research papers and more than 60 clinical trials have established that phosphatidylserine (Phosphatidylserine ) can rejuvenate your brain cell membranes and thereby:
- strengthen your memory,
- increase vigilance and attention,
- boost learning,
- increase mental acuity,
- intensify your concentration,
- relieve depression and improve mood,
- inhibit exercise and stress induced increases in cortisol,
- decrease stress—whether you are young or old.
How Does Phosphatidyl Serine Work?
Phosphatidylserine restores your brain's supply and output of acetylcholine, a neurotransmitter essential to memory.
Phosphatidylserine enables your brain cells to metabolize glucose and to release and bind with neurotransmitters, all of which is important to learning, memory and other cognitive functions.
Phosphatidylserine increases communication between cells in your brain by increasing the number of membrane receptor sites for receiving messages. Phosphatidylserine modulates the fluidity of cell membranes, essential to your brain cells' ability to send and receive chemical communication.
Scientific studies demonstrate that phosphatidylserine restores the brain's supply and output of acetylcholine, the neurotransmitter so important to memory, and so may turn back the clock in an aging brain.
Phosphatidylserine restores your brain's supply and output of dopamine, essential to memory, attention and problem-solving.
Phosphatidylserine can increase the availability of endogenous (that which is created within your cells) choline for de novo synthesis and release (while similar treatments with phosphatidylcholine had no effect).
Phosphatidylserine also stimulates your brain to produce dopamine and this is likely why patients diagnosed with clinical depression have shown marked improvement in their symptoms as a result of taking phosphatidylserine daily. Reduced dopamine levels are also thought to contribute to attention deficit disorder and this natural substance has proven to be an effective therapeutic agent for ADD and ADHD.
Phosphatidylserine inhibits stress- and exercise-induced increases in Cortisol.
Studies examining athletes involved in cycling, weight training and endurance running show that phosphatidylserine can speed recovery, prevent muscle soreness and help athletes to feel their best during the rigors of training.
We also know that phosphatidylserine is important in bone matrix formation, testicular function, beat coordination of the heart, hormone secretion by the adrenal glands and cell repair and removal by the immune system.
Modern science has only begun to understand how important phosphatidylserine is to our bodies. After all, it's present in every type of cell in our body and the membrane proteins that it activates are important in all cells.
Why Do I Need Phosphatidyl Serine?
Your body cannot produce phosphatidylserine in sufficient amounts when under stress, when aged, or when lacking in the necessary enzymes and metabolic cofactors.
Because of stress, aging, and our modern eating habits and food-production methods.
Stress: Like burning a candle burning at both ends, stress increases the demand for phosphatidylserine and depletes your phosphatidylserine levels at the same time.
Aging: The elderly particularly benefit from taking phosphatidylserine. While aging increases our brain's need for phosphatidylserine it also creates digestive and metabolic inefficiency so that it's simply not possible to get enough phosphatidylserine in your diet. Considerable research has proven that it improves age-associated memory impairment, and continued use prevents age-related decay of brain functions.
(Above:) Changes in daily phosphatidylserine (PHOSPHATIDYLSERINE) consumption.
Modern Diets: Modern low-fat and low-cholesterol diets lack up to 150 mg per day of dietary phosphatidylserine. A vegetarian diet may undersupply as much as 200 to 250 mg per day. Other eating styles also create a demand for more phosphatidyl serine. For example, a diet deficient in omega-3 fatty acids may reduce the amount of phosphatidylserine in the brain by 28% and thereby impair your brain's ability to form, store, process and remember.
Modern Food Production:
To make matters worse, modern industrial production of fats and oils decreases all of the natural phospholipids, including phosphatidylserine.
What is Phosphatidylserine (PS)?
Phosphatidylserine includes amino and fatty acids such as docosahexaenoic acid (DHA).
Phosphatidylserine is a phospholipid that is vital to your brain cells. Phospholipids are molecules containing both amino and fatty acids found in every cell membrane within our bodies. The fatty acids include omega-3 and omega-6 fatty acid molecules—essential for life.
Actually, phosphatidylserine is universally present in living things from the most simple to the most complex. It is present in every one of our cells. Phosphatidylserine has many known functions throughout all of our tissues and organs, but is most important as the key building block for the billions of cells that make up our brain.
First isolated in 1942, phosphatidylserine is now available as a dietary supplement derived from soy lecithin.